Published Paper Details:

ABSTRACT Objective: The objective of the present study was to develop self-emulsifying drug delivery system (SEDDS) of Silymarin to improve its solubility, in vitro dissolution efficiencies, and further the bioavailability) Materials and Methods: The solubility of silymarin in various oils, surfactants, and cosurfactants was determined. Pseudotemary phase diagrams were constructed using Capryol 90, Transcuto P,Span 80 to identify the efficient self-microemulsification region. Prepared SEDDS was evaluated for emulsification time, drug content, droplet size, and in vitro dissolution. Results and Discussion: The optimized formulation F3 had shown the smallest particle size, maximum solubility, less emulsification time, drug stability in water, and improved in vitro release. In the present study, already existed historical data were used for importing data. Optimized SEDDS Silymarin formulation (F3) prepared had shown improved in vitro release when compared to commercial formulation. Conclusion: It was concluded that SEDDS would be a promising drug delivery system for poorly water-soluble drugs through oral route.