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Background: Most of the things that man uses (the food, cloth, cosmetics, drugs, etc are derived from plants or use or need a product derived from plants). With the increase in global population and industrialization, the whole world is devising means of producing products that are safe, cheap, readily available and environmentally friendly to meet the needs of the growing population. This, will therefore, lead to complete utilization of plant resources which will in turn help in achieving the sustainable development goals. Materials and Methods: The leaves of three different plants, Kigelia Africana, Mitracarpus hirtus and Bryophyillum pinnatumwere investigated for the presence of secondary metabolites (flavonoids). The leaves Were defatted with n- hexane and was extracted with methanol. The methanol extract was purified by fractionation methods using solvent mixtures of water, n- hexane and t-butylmethylether (90:9:1), the aqueous phase was farther purified by successive extraction with n- hexane, ethyl acetate and acetone. The acetone extract was then used for the 1solation of flavonoids using liquid chromatography using n- hexane: ethylacetate mixture (20:80) as a solvent. The flavonoids isolated were phytochemically screened, tested for their antioxidant activity and antimicrobial activities against Salmonella typhi, Stapiylococcs aureus and candida albicans. Also, the isolates were used in the production of antioxidant concentrate which was applied in the production of a household cosmetic product (body cream). Results: The results showed that all the isolates contain flavonoids which have varying antioxidant activities as compared to the standard (Quercetin). Also, Kigelia Africana had high level of antimicrobial activities against Candida albicans, Mitracarpus hirtus had good antimicrobial activity against Staphylococcus aureus while Bryophyillum pinnatumshowed no antimicrobial activity against all the test organisms. Conclusion: The body cream produced using the antioxidant concentrate showed that it was good and acceptable within analytical test limits.