Published Paper Details:

Brain, the center of the nervous system in all vertebrate, performs the maximum essential role in each function of human body. However, many neurodegenerative diseases, most cancers and infections of the brain become more prevalent as populations become older. In spite of the primary advances in neuroscience, many potential therapeutics are still unable to reach the central nervous system (CNS) because of the blood-brain barrier (BBB) that is shaped by the tight junctions in the capillary endothelium of the vertebrate brain. This effects withinside the capillary wall behaving as a continuous lipid bilayer and preventing the passage of polar and lipid insoluble substances. Several techniques for handing over drugs to the CNS had been advanced to decorate the ability of therapeutic molecules to cross the BBB by modifying the drug itself, or by coupling it to a vector for receptor-mediated, carrier mediated or adsorption-mediated transcytosis. The brain is a sensitive organ, and evolution constructed very efficient methods to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemical compounds also can frustrate therapeutic interventions. Many existing prescription drugs are rendered ineffective withinside the treatment of cerebral illnesses because of our incapability to effectively deliver and maintain them inside the mind. General strategies that could help drug delivery to the brain easily are interestingly and systematically explained in this review.