Published Paper Details:

Cadmium is a lethal heavy metal that can cause diverse tissue toxicities and pathologies. Conversely, Aloe vera is a natural anti-oxidant that can ameliorate cytotoxic effects of tissue toxicants. In this study, the objective was to assess the protective effect of Aloe vera against Cadmium-induced toxicity in liver of Swiss albino mice. Mice were divided into 3 groups of 4 animals each. This current study was performed by the Morphological observations and by the analysis of biochemical parameters in mice as affected by the oral administration of a single dose equivalent to 1/20 from LD50 (100 mg/kg B.W.) of Cadmium individually for 21 days. The results from present study showed a significant (P <0.05) reduction of the body weight total cholesterol and total Protein due to Cadmium exposure. Oral administration of Cd reduced GSH level and activities of antioxidant enzymes were significantly reduced in Cd treated group. The co-treatment of Aloe with Cd was very effective and it significantly reversed the Cd induced biochemical alterations almost similar to that of control. Aloe vera was able to improve the cellular redox system in mice treated with Cd. It can be concluded that Aloe vera has protective effects against Cd-induced oxidative damage.