Published Paper Details:

: Low aqueous solubility and oral bioavailability is a main concern for the formulation research scientist in the field of modern drug delivery system. In recent years much more attention has been focused on the development of self-emulsifying drug delivery system which is one of the most promising approaches to improve the bioavailability of hydrophobic drugs. The SEDDS is isotropic mixture of drug, oil, surfactants, co surfactants form emulsion on mixing with water with energy. This conventional SEDDS prepared in the form of liquid and semisolid which can offer some demerits. So Solid self-emulsifying drug delivery system (S-SEDDS) which is formulated by solidification of liquid and semisolid self-emulsifying ingredients into various solid dosage form such as powders, tablet, capsule, solid dispersion etc. by various methods such as melt granulation, melt extrusion, spray drying, adsorption to solid carriers. The review presents in this article provides an updated knowledge of the recent trends in S-SEDDS with related to the selection of the ingredients, dosage form developments, solidification methods associated with problems and their remedies, evaluation and their application. Finally, the present problems and the possible future investigation in this field is pointed out in this review article.