Published Paper Details:

The major goal of this study is to develop and test a pulsatile drug delivery system for the medication Dapagliflozin in order to achieve time-specific release. The PDDS (Pulsatile Medicine Delivery System) delivers the drug at the correct time, right place of action, amount, providing greater benefits than traditional dose forms and boosting patient compliance. These systems are designed to work with the body's circadian rhythms, and the medicine is released as a pulse after a lag period. A Dapagliflozin rapid disintegrating core tablet was made utilising Croscarmellose sodium (MCC), Lactose, Talc, and Magnesium stearate in a direct compression process. The core tablet was then coated using a press coating procedure with a mixture of Ethyl Cellulose (EC), a hydrophobic polymer, and Hydroxypropyl Methyl Cellulose (HPMC), a hydrophilic polymer. Various weight ratios of Hydroxypropyl Methyl Cellulose (HPMC K4M) and Ethyl Cellulose (200:0, 150:50, 100:100, 50:150, 0:200) were pressed coated over Dapagliflozin core tablets to release Dapagliflozin after a 4 hour lag period. The pre-compression and post-compression characteristics of prepared tablets were assessed. The best results were obtained in formulations containing 50:50 weight ratios of HPMC K4M and Ethyl Cellulose. This is a viable formulation for Dapagliflozin pulsatile medication delivery in diabetes. Using an equal blend of Hydroxypropyl Methyl Cellulose and Ethyl Cellulose, a pulsatile drug delivery system for Dapagliflozin and other medicines can be produced.