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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
FORMULATION AND EVALUATION OF BUCCO-ADHESIVE TABLET OF ANTI-DIABETIC AGENT.
Authors
Kajal S. Jumde, Nishan N. Bobade, Chitralekha G. Therkar, Ketakee A. Nichat, Mohd. Vaqqas Quraishi
Keywords
Pioglitazone Hydrochloride, Bioadhesion, HPMC K4M, HPMC K15M, Carbopol 934P, Sodium Alginate.
Abstract
The aim of this work was to investigate and describe mucoadhesive buccal tablets of pioglitazone hydrochloride utilising a variety of bioadhesive polymers in combination, including sodium alginate, carbopol, HPMC K4M, and HPMC K15M. TEN formulations were created with various polymer concentrations and combinations of two polymers in each formulation. Individual polymers make up formulations F1 to F4. F5 to F10 were made up of two polymer combinations. Physicochemical criteria such as hardness, thickness uniformity, weight fluctuation, and surface pH were assessed on the produced tablets. The bioadhesive strength and in-vitro drug release of the produced tablets were also tested. In vitro bioadhesive strength and release tests revealed that formulation F2, which had individual polymer and medication, had the best drug release (97.51%) and bioadhesive strength. The FTIR measurements revealed no evidence of interaction between polymer and drug.
IJCRT's Publication Details
Unique Identification Number - IJCRT2205464
Paper ID - 220081
Page Number(s) - e153-e168
Pubished in - Volume 10 | Issue 5 | May 2022
DOI (Digital Object Identifier) - http://doi.one/10.1729/Journal.30263
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Kajal S. Jumde, Nishan N. Bobade, Chitralekha G. Therkar, Ketakee A. Nichat, Mohd. Vaqqas Quraishi, "FORMULATION AND EVALUATION OF BUCCO-ADHESIVE TABLET OF ANTI-DIABETIC AGENT.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 5, pp.e153-e168, May 2022, Available at :http://www.ijcrt.org/papers/IJCRT2205464.pdf
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Volume 12 | Issue 7
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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