Published Paper Details:

The most preferred route for the treatment of numerous diseases and disorders is oral dosage form, although the gut wall has a number of barriers to drug administration. Colon is a site where both local and systemic delivery of drugs can take place. Local delivery could, allow topical treatment of bowel diseases, ulcerative colitis. Systemic side effects could also be reduced. To achieve successful colonic delivery, a drug must be protected from absorption in the upper gastrointestinal tract (GIT) environment before being released into the proximal colon, which is thought to be the optimum site for colon-targeted drug delivery. Conventional approaches for CDDS (Colon Specific Drug Delivery), which includes prodrugs, pH and time dependent system and microbially triggered system, polysaccharides-based delivery system has achieved limited success and having its limitations. Newly developed CDDS which includes pressure -controlled drug delivery system, CODES technology, and osmotic controlled drug delivery are unique in terms of achieving in vivo site specificity and feasibility. Polymeric approaches CDDS includes reservoir system with rupturable polymeric coating, reservoir system with soluble or eroding polymeric coatings has been achieved. These advance or/and novel approaches are effective and unique in terms of achieving in vivo site specificity and feasibility for colonic drug delivery.