Published Paper Details:

Gastro retentive drug delivery system are prepared with the intention to retain drug in the gastric region for a prolonged time and release incorporated drug candidates and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal tract (GIT) thus leading its optimal bioavailability. Gastro-retentive drug delivery systems are the system in which drug can be hold in the stomach. These drug delivery Systems is one of the most common gastro-retentive dosage forms used to achieve increased GRT and reduces fluctuation in plasma drug concentration. The main objective of writing this review on floating drug delivery systems was to accomplish the recent literature floating mechanism to achieve gastric retention time. Gastro-intestinal dosage forms provides many advantages like- Improved drug absorption, because of increased gastric residence time and more time spent by the dosage form at its absorption site. This review consist the detailed study of floating drug delivery system, approaches such as Single unit dosage forms, Multiple unit dosage forms and Raft-forming systems, consist advantages and disadvantages of floating drug delivery system, also consist gastric residence time of an oral dosage form contains factors affecting efficacy and various applications of the system like- sustained drug delivery, enhanced bioavailability, enhanced absorption, Reduced fluctuations of drug concentration, Site-specific dosage forms, and decreased undesirable activity at the colon.