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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
SOLID DISPERSION AS A STRATEGIC METHOD FOR POORLY SOLUBLE DRUGS AND SOLUBILITY IMPROVEMENT TECHNIQUES FOR POORLY SOLUBLE DRUGS
Authors
Dr.Sonali Mahaparale, Ms.Deepa Prabhakar Pandey
Keywords
Solubility, bioavailability, solid dispersion, cocrystallization, poorly soluble drugs, lipophilic
Abstract
The solubility of medication is defined as the highest quantity of solute that will disintegrate in a particular amount of solvent at a fixed temperature and pressure under equilibrium conditions. Solubility is a crucial factor for a drug before the absorption takes place the drug must be perfectly soluble. The development of amorphous solid dispersions, salt formation, crystallization, prodrug production, and particle size reduction are all common strategies for increasing an API's dissolving rate and/or solubility.(1) API's dissolving rate and solubility are increased, its stability is boosted, and subsequent processing is enhanced without any chemical modifications. Solid dispersion has got a lot of attention as a way to improve the dissolution rate and thus the bioavailability of hydrophobic medicines.
IJCRT's Publication Details
Unique Identification Number - IJCRT2203180
Paper ID - 216362
Page Number(s) - b536-b544
Pubished in - Volume 10 | Issue 3 | March 2022
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Dr.Sonali Mahaparale, Ms.Deepa Prabhakar Pandey, "SOLID DISPERSION AS A STRATEGIC METHOD FOR POORLY SOLUBLE DRUGS AND SOLUBILITY IMPROVEMENT TECHNIQUES FOR POORLY SOLUBLE DRUGS", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 3, pp.b536-b544, March 2022, Available at :http://www.ijcrt.org/papers/IJCRT2203180.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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