Published Paper Details:

Mucoadhesive drug system interact with the mucus layer covering the mucosal epithelial surface, mucin molecular and increase the residence time of the dosage form at the site of absorption. Mucosal adhesion is backed by several theories which include electronic, absorption, wetting, diffusion, fracture and mechanical. Stages of mucoadhesion include contact stage and consolidation stage. Mucoadhesion while considering drug delivery is having several merits, because of the ideal physiochemical characters of the mucosal membrane by ionic bonds, covalent bonds, van-der-waal bonds and hydrogen bond. Various sites for mucoadhesive drug delivery system are ocular, nasal, buccal cavity; GIT, vaginal, rectal and several specific dosage forms have been reported. Factors affecting mucoadhesion are , presence of carboxylate group and density. several synthetic and natural polymers are identified assuitable candidates for mucoadhesive formulation. EX-vivo/in-vitro studies utilizing gut sac of rate provides indepth knowledge about the adhesive property of the dosage form as well as polymers.