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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
DESIGN AND EVALUATION OF SUSTAINED RELEASE METAPROLOL SUCCINATE SUPPOSITORY BY NON- AQUEOUS SOLVENT EVAPORATION TECHNIQUE
Authors
Mr. Shivraj Sopan Dhage, Dr. Vishal Bharat Babar, Mr. Amit Vilasrao Pondkule, Mr. Sudarshan Narayan Nagarale
Keywords
Polymer, Suppository, Microsphere.
Abstract
The aim of the present study is to prepare a sustained release suppository of an antihypertensive drug suitable for rectal administration.
Firstly, the microspheres of metaprolol succinate were formulated using ethyl cellulose as polymer to sustain the drug release for longer time to conquer the short half life of the drug. The microspheres using ethyl cellulose were prepared by non-aqueous solvent evaporation technique. The microspheres were evaluated for micromeritic properties, particle size, percentage yield, entrapment efficiency, drug polymer compatibility, scanning electron microscopy and in-vitro drug release studies.
IJCRT's Publication Details
Unique Identification Number - IJCRT2201218
Paper ID - 214844
Page Number(s) - b751-b759
Pubished in - Volume 10 | Issue 1 | January 2022
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Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Mr. Shivraj Sopan Dhage, Dr. Vishal Bharat Babar, Mr. Amit Vilasrao Pondkule, Mr. Sudarshan Narayan Nagarale, "DESIGN AND EVALUATION OF SUSTAINED RELEASE METAPROLOL SUCCINATE SUPPOSITORY BY NON- AQUEOUS SOLVENT EVAPORATION TECHNIQUE", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.10, Issue 1, pp.b751-b759, January 2022, Available at :http://www.ijcrt.org/papers/IJCRT2201218.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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