Published Paper Details:

Objective The main goals of the current study were to improve patient compliance and develop a two-layer drug delivery system that would allow for drug release at a predetermined time following an initial release. This would allow for sustained drug release from the formulation during the effective treatment of arthritis. Increasing the bioavailability of etodolac and etoricoxib was the aim of the current investigation. Methods An immediate release layer and a sustain release layer made up the two distinct components of the created Biayer drug delivery system. Crosspovidone was included in the immediate release layer together with the active component as a super disintegrant. Using the wet granulation process, the tablet was made. Kolloidon SR was used as a release-delaying polymer in the sustained release layer. Sustain release layer preparation was done using the direct compression method. Result The developed formulations were assessed for their in vitro drug release profile, in vitro disintegration time, and physical properties. Conclusion On the basis of these evaluation shown that optimized bilayer tablets formulation F5 showed 12 hrs drug release of Etodolac and F8 showed disintegration time is 36 sec for immediate release. The bilayer formulation by factorial showed compliance with treatment of Arthritis.