Published Paper Details:

Fenofibrate is a lipid lowering drug used in the treatment of hyperlipidemia, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid to enhance solubility of drug by using solid dispersions technique. Solid dispersions of Fenofibrate were prepared and evaluated by using ?-cyclodextrin in different ratios (1:1, 1:2, 1:3, 1:4, 1:5). The effect of kneading method of preparation of solid dispersion on solubility behavior was also investigated. Solid dispersions containing Fenofibrate /?-cyclodextrin formulation provide a promising way to enhance solubilty of fenofibrate. In the formulations of the Fenofibrate and Beta cyclodextrin, Formulation (1:5) shows the great enhance in solubility than pure drug. Beta-cyclodextrin was chosen as the carrier because it has high hydrophilicity, non-toxic, inert, economical. Thus the solubility and bioavailability of fenofibrate was enhanced by the preparation of solid dispersion by kneading method.