Published Paper Details:

Advancements in dermatology and cosmetics emphasize the significance of skin rejuvenationand regeneration. Hydrogels have emerged as a favorable platform for delivering active agents due to their biocompatibility, hydration potential, and controlled release characteristics. This study focused on creating and evaluating a hydrogel containing allantoin, intended to facilitate skin revitalization and renewal. The hydrogel formulation was meticulously crafted by combining natural and synthetic polymers, optimized to achieve desired viscosity, gel strength, and allantoin-loading capacity. Allantoin, recognized for its skin-calming, hydrating, and regenerative attributes, was successfully integrated into the hydrogel matrix. Comprehensive characterization of the hydrogel encompassed assessments of physicochemical attributes such as pH, rheological performance, drug release kinetics, and mechanical properties. In vitro release profiles exhibited a sustained and controlled release of allantoin from the hydrogel spanning hours, indicating its potential for prolonged topical application. Rheological analysis unveilled the hydrogel's shear-thinning behavior, a property that augments its ease of application. Mechanical testing ascertained the hydrogel's mechanical robustness, establishing its suitability for skin contact. Biocompatibility and cytotoxicity evaluations employing human skin fibroblast cells corroborated the hydrogel's cell-friendly nature and its potential to encourage cellular proliferation. These results imply that the allantoin-infused hydrogel holds promise for stimulating skin regeneration. Furthermore, the hydrogel's efficacy in retaining skin moisture was validated through tests on a skin-equivalent model. In summary, the allantoin-loaded hydrogel formulation boasts favorable physicochemical attributes, sustained release kinetics, and biocompatibility. This positions it as a viable contender for fostering skin revitalization and renewal. Further validation through in vivo studies is imperative to establish its clinical efficacy and safety. The hydrogel formulation presents a pioneering approach to addressing diverse skin-related concerns and advancing dermatological and skincare treatments.