Published Paper Details:

Breast cancer is a malignant, uncontrolled growth of epithelial cells lining the ducts or lobules of breast tissue arising through a series of molecular mutations at the cellular level. It is the most commonly occurring cancer and the leading cause of cancer death in females worldwide. In 2008 alone, 1.38 million new cases of breast cancer were diagnosed and 458,400 women died of breast cancer. The causes of most breast cancer cases remain to be unknown. However, recent years have shown numerous advances in the identification of various risk factors including gender, environment, hormones, genetic factors, and lifestyle. The incidence of breast cancer among women may increase with advancing age, late age at first birth (>= 30), the use of postmenopausal hormone replacement therapy, prior family history, higher dietary fat intake, obesity, and alcohol intake (Michaud et al., 2008). Curcumin is the principal active component of Indian curry spice turmeric and has been found to exert preventive and therapeutic effects in various cancers. Apart from this cruciferous vegetable compound isothiocyanates shown therapeutic effects. This is, in part, due to its ability to influence a diverse range of molecular targets and signaling pathways the effect of the dimethoxycurcumin and benzyl isothiocyanates will be tested on MCF-7 and MDA MB231 cell lines.