Published Paper Details:

Aim & Objective - This study was designed to compare the antiemetic efficacy of Ondansetron, Dexamethasone and combination of both (Ondansetron & Dexamethasone) for reducing PONV and to assess advantage of one drug over the other. Material and Method - A total of 270 patients of age Group 18 to 65 years, with ASA I and II, scheduled for open cholecystectomy under spinal anesthesia , They were divided into 3 Groups i.e. Group O, Group D & Group O + D. Frequency of Retching, Nausea & Vomiting, need of another drug and patients satisfaction were noted for next 24 hours . Result - The incidence of nausea and vomiting was highest in Group O i.e., 87%, in Group D it is 70% and in Group O+D it is 10% during Intraoperative period (0-1 hr), incidence of nausea and vomiting was less in 1-6 hour period as compared to 0-1 hr. Incidence of nausea and vomiting was high in intra-operative period in both the Groups (Group O and Group D) as compared to Group O+D and it was statistically significant (p<0.05). On comparing with Group O & Group O+D it was statistically significant (p<0.005). Conclusion - Combination of Ondansetron and Dexamethasone are very effective for PONV, and have great patient satisfaction.