Published Paper Details:

Autacoids are chemical substances that our body releases periodically that act as local hormones. They are released due to various stimuli and bring about various physiological changes in the body. Autacoids handle several biological actions including modulation of the activity of smooth muscles, glands, nerves, platelets and other tissues.Typically, autacoids are short-lived and rapidly degraded. Autacoid modulators interfere with the synthesis, inhibit the release or the receptors upon which they act. Autacoids are biological factors synthesized and released locally that play a role in vasoconstriction, vasodilation, and inflammation. These include serotonin,bradykinin, histamine, and eicosanoids. Vertebrates have evolved remarkable mechanisms for the repair and maintenance of their own tissues (i.e.,host tissues) that simultaneously preclude the invasion and growth of non-host cells and viruses. The front line of host defense relies on the skin, mucosal surfaces, and cornea, where epithelial tissues provide not only the critical physical barrier to a constant exposure to pathogens, but also an interface with commensal microbes.] Inflammation is a major component of host defense, and a fundamental feature of this vital response is the recruitment of leukocytes to sites of injury.Polymorphonuclear leukocytes (PMN) and macrophages in particular are essential for preventing infection and the concomitant threat of life-threatening sepsis. Indeed, in humans, vulnerability to infection is an inevitable consequence of all known genetic or acquired defects in leukocyte function, including defects in adhesion, microbial killing, and phagocytes; deficiencies in the generation of leukocytes in the bone marrow increase rates of infection and also other illnesses and raise mortality rates.In fact, any injury that compromises the external epithelial barrier triggers a robust inflammatory response.