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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY
Authors
Mr. Tushar Ramesh Pandhare, Prof. Yogesh Nanasaheb Gavhane
Keywords
Abstract
In situ gels have been considered as promising drug delivery system
for Ketorolac Tromethamine, since they have been shown to sustain the drug release up to 7 hours. The main objective of this study was to prepare and characterize in situ gel of Ketorolac Tromethanine. Gels were prepared using Sodium Alginate as the Ion Sensitive polymer and HPMC K4M, as viscosity Enhancer using the Ion Gelation method. Central composite experimental design was employed for the optimization of the effect of independent variables on the response (Viscosity, and % drug diffusion). Gels were evaluated for clarity, appearance, Gelling Capacity, and their performance in vitro and ex vivo using Franz diffusion cell. According to the findings of this research, an in situ gel of Ketorolac Tromathamine could be considered as a conceivable drug delivery system for treatment of post-surgical swelling.
IJCRT's Publication Details
Unique Identification Number - IJCRT2110366
Paper ID - 212783
Page Number(s) - d124-d145
Pubished in - Volume 9 | Issue 10 | October 2021
DOI (Digital Object Identifier) - http://doi.one/10.1729/Journal.28445
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Mr. Tushar Ramesh Pandhare, Prof. Yogesh Nanasaheb Gavhane, "DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 10, pp.d124-d145, October 2021, Available at :http://www.ijcrt.org/papers/IJCRT2110366.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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