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ABSTRACT Virechana Karma is the second procedure in Panchakarma which is considered as the best therapy to pacify pitta dosha. It is not only beneficial in adult but also in pediatric age group. There are many references that advocate Virechana therapy in children, like in case of eight types of pidika in children in Kashyapa Samhita, susnigdha Virechana has been mentioned. In fakka roga treatment shodhana (Virechana) with trivrita kshir (milk processed with operculina turpithum) is advised. Many other references are also available that indicated benefits of Virechana karma in children. It purifies Rasa-Raktadi dhatu, produces alertness in sensory system (Indriyas). Main indications of Virechana karma in children are Mandagni, Vishamagni, Arochaka, Avipaka, Gulma, Udavarta, Udara roga, pleeha, Pakvvashaya Ruja, Alsaka, Vibandha, Anaha, Chhardi, Krimikostha, Visarpa, Galaganda, Granthi, Apachi, Visphotak, Shwitra, Halimaka, Kamla, Pandu, Shwasa, Kasa etc. The commonly used Virechana drugs (therapeutic purgative) and virechanopaga (purgative associate) medicines in children are Draksha, Trivrita, Haritaki, Aragvadha, Ksheera, Triphala, Gandharva Taila. In pediatric age group there is predominance of Kapha in the body. Virechana karma occurs properly in the condition of manda (mild) kapha so there is need to treat kapha before performing Virechana in children. Virechana drugs in children should be palatable and generally mridu (mild) Virechana should be preferred.