Published Paper Details:

Ophthalmic drug delivery is one of the most widely used drug delivery systems for the delivery drug to eye section. In situ gels are a type of formulations in which drug is ingested in solution form and while coming in contact with body fluids or temperature, it gets converted to gel form in order to produce a sustained release formulation. The objective of present work is to develop in situ gel of ofloxacin which is an antibiotic for bacterial infections.it is a type of broad spectrum antibiotic. It has a low molecular weight of 361.368gm/mol. It is one of the most suitable candidates for ophthalmic drug delivery. Ofloxacin is an antibiotic that is used to treat bacterial infections; it stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA).Marketed eye drop solution is cleared very rapidly from the corneal region whereas, in-situ gelling systems, it was observed that clearing time is slow and retention of drug is for longer period at the corneal surface for a longer duration Ofloxacin can be targeted in treatment of the bacterial infection and also reduce dosing frequency, increase bioavailability of Ofloxacin that will result in better patient compliance with minimum side effects.