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Nanoparticles have wide applications in various fields due to their small size. Under this the plant based nanoparticles has many advantages over conventional physio-chemical methods and has various applications in medicine. In present study the zinc oxide nanoparticles were synthesized using the extracts of petroselinum crispum and piper beetle. 0.01 M zinc acetate dehydrate was used as a precursor in leaf extracts of respective plants for nanoparticles synthesis. The sol-gel route remediation of the zincoxide from the environment is an important step, and it can be achieved by using physical process like sedimentation and filtration. The structural and optical properties were investigated by using X-ray diffraction (XRD) method, Uv-Vis. Morphological analysis by Scanning electron microscope (SEM). The green route of synthesis is rather safe and eco-friendly when compared to chemical route and could be used for the fabrication of Zinc oxide nanoparticles as an antimicrobial agent.