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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
FORMULATION AND DEVELOPMENT OF SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG, HYDROCHLOROTHIAZIDE, WITH THE HELP OF MIXED SOLVENCY CONCEPT AND THEIR EVALUATIONS.
Authors
Diksha Joshi, Mr. Abhishek Sah, Dr. R.K. Maheshwari
Keywords
Mixed Solvency Concept, Hydrotropy, Hydrochlorothiazide, Solid Dispersion, Solubility.
Abstract
The aim of the present research work is to explore the application of mixed solvency concept to formulate and
develop a fast dissolving solid dispersion. In the present study, poorly soluble drug, hydrochlorothiazide
(model drug) was tried to be solubilized by employing the combination of physiologically compatible water
soluble additives (solubilizers) to formulate its fast dissolving solid dispersion. For poorly water soluble drug
hydrochlorothiazide, combination of solubilizers such as sodium caprylate, sodium benzoate, sodium acetate,
lysine hydrochloride, and poloxomer 407 as mixed solvent systems were used to decrease the overall
concentration of solubilizer required to produce substantial increase in solubility of hydrochlorothiazide. The
procured sample of hydrochlorothiazide was characterized by melting point, UV, and DSC studies. Mixed
solvency concept has been successfully employed for enhancing drug loading of poorly water soluble drug,
hydrochlorothiazide.
IJCRT's Publication Details
Unique Identification Number - IJCRT2109243
Paper ID - 211903
Page Number(s) - c268-c285
Pubished in - Volume 9 | Issue 9 | September 2021
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Diksha Joshi, Mr. Abhishek Sah, Dr. R.K. Maheshwari, "FORMULATION AND DEVELOPMENT OF SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG, HYDROCHLOROTHIAZIDE, WITH THE HELP OF MIXED SOLVENCY CONCEPT AND THEIR EVALUATIONS.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.9, Issue 9, pp.c268-c285, September 2021, Available at :http://www.ijcrt.org/papers/IJCRT2109243.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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