Published Paper Details:

Solubility of poorly water-soluble drugs has been a really vital issue in screening studies of new chemical entities as well as formulation research. Drug efficacy can be restricted by poor aqueous solubility. Therefore, solubilization of poorly water-soluble drug is encountered on challenging factor. Poor solubility of any drug or chemical entity directly affects its bioavailability, as bioavailability is dependent on several factors like drug solubility and permeation across biological membranes. Various methodologies have been employed to enhance the aqueous solubility of poorly water-soluble drug. Hydrotropic solubilization is one of them. Hydrotropic solubilization is the process of enhancement in aqueous solubility of poorly water-soluble drugs in presence of large concentration of a hydrotropic agent or hydrotropes. Hydrotropes possess the ability to increase the solubility of drug. Various hydrotropic agents such as sodium benzoate, sodium citrate, niacinamide, sodium caprylate, sodium acetate, sodium ascorbate, sodium gluconate, urea etc., have been employed to increase the solubility of poorly water-soluble drugs. Mixed hydrotropic solubilization is a novel and advance way for enhancement in solubility of poorly water-soluble drugs by using different hydrotropic agents in small and safe concentrations to reduce the toxicities.