Published Paper Details:

: Anticancer, anticoagulant as well as various activity shows by natural coumarin due to its metabolite derivative (7-hydroxycoumarin). This review article is based upon the various aspects like pharmacological activities along with its pharmacokinetic, different sources of coumarins, biosynthesis pathway, its analysis and characterization of coumarin derivatives etc. Therefore the main target of this article is to study of various derivatives of coumarin along with its pharmacological effect of it. The release of Cyclin D1 ( this is over expressed in different types of cancer) inhibited by 7-hydroxycoumarin has been shown in recent studies that are reported in many articles, this approach gives better idea about its needs in the treatment of various types of cancer. Coumarin derivatives like Esculetin that inhibits the growth and cell cycle by blocking the G1 phase in HL-60 leukemia cell which result into block the phosphorylation of retinoblastoma protein. Flavonoids also show therapeutic action in various types of leukemia treatment and in patient with HIV disorder. Genistein is isoflavone which block the tyrosine kinase enzyme blocker that has inhibitory effects on cell growth of different types of carcinoma cell lines, due to this is the best suitable candidate for cancer treatment. These are two compound having more potent inhibitory effects on cell growth of different cancer as compared to other compound.