Published Paper Details:

Objective- Chitosan is derived from chitin through deacetylation process. Production of Chitosan takes place in 4 steps. Chitosan is natural cationic polysaccharide which is rich in source. Chitosan has unique physiochemical properties, good biocompatibility and satisfactory biodegradability. Chitosan contain amino group. Chitosan has been popular biomaterial in pharmaceutics from decades and widely used in drug delivery. Chitin is extracted by removing protein and calcium carbonate from the raw shell. Purpose- Chitosan is soluble in acidic solution but precipitate obtained i.e. solids has very high PH values. By treating Chitosan with various PH, changes in their physical forms can be seen. Basically Chitosan is non-toxic to humans, plants, animals and because of its lack in toxicity where lot of application can be observed in environmental, agricultural, food, pharmaceutical industry. The importance of Chitosan can be also seen in drug delivery in humans to solve various diseases. Results- Due to its sub-micron size it is suitable for mucosal routes i.e. oral, nasal and ocular nanoparticle showed to be a good adjuvant for vaccine development. Chitosan is also used is polymeric nanoparticle through various route. Chitosan is added in aqueous acidic solution and then the aqueous solution of TPP is added under vigorous stirring. In this Anionic molecules diffuse in positively charged chitosan molecule and then crosslinking occurs leading to nanoparticle formation. Various production method for drug delivery take place. Using multiple method, application can also be seen in Covid-19 drug delivery.