Published Paper Details:

The mean platelet volume (MPV) is an inflammatory marker which suggest the activation Platelets .There are number of studies which suggest the association between the neoplastic process and metastasis of cancer . Here we have conducted a retrospective analysis to find the role of MPV as a prognostic informative marker in gall bladder cancer This study includes a retrospective analysis of 73 patients with gall bladder cancer who Underwent treatment for gall bladder cancer with curative or palliative intent . MPV was obtained and statistically analysed to find association between the nodal status (N) , overall stage as per American Joint Committee on Cancer (AJCC) staging system, perineural invasion and differentiation of the tumor ,using Statistical Package for the Social Sciences (SPSS) software (IBM corp. version 23). It was seen in this study that MPV values were significantly high in nodal positive cases (OR 3.623 ,95% CI (7.778-1.687) ; p value -0.0001), advanced stage (OR 3.623 ,95 % CI (7.778-1.687) ; p value of 0.0001) , perineural invasion (OR 3.396 , 95 %CI (8.319- 1.387 ) ; p value -0.0001) , poor differentiation (OR 2.327 , 95 % CI (4,651-1.164) ; p value -0.002 ).MPV is an inflammatory marker which relates the nodal positivity in staging and prognostication of gall bladder cancer . This marker is inexpensive and can be done conveniently aiding in ascertaining risk status of gall bladder cancer