Published Paper Details:

Phyllanthus amarus has long been used as a medicinal herb. This plant has been used to cure a variety of severe ailments traditionally, and it has been scientifically proven to be safe and effective against a variety of ailments. The aim of this research was to see whether the separated alkaloid rich fraction from P.amarus has any hepatoprotective property. We successfully isolated the alkaloid fraction from this plant and tested it on male albino rats suffering with D-galactosamine induced hepatitis. We looked at endogenous antioxidant enzymes in the liver tissue to see whether alkaloid fraction has hepatoprotective activity. The results showed that antioxidant enzymes such SOD, CAT, GR, GPx, and GSH levels were considerably higher in the alkaloid rich fraction that treated to hepatitis group, but they were lower in the hepatitis alone rat group. In addition, in the hepatitis group, however, GST enzyme activity and lipid peroxidation in the form of MDA were significantly higher, but these values were also considerably decreased in the alkaloid rich fraction treatment of hepatitis rats. In conclusion, the alkaloid-rich fraction separated from P.amarus displays hepatoprotective effects in the liver via boosting endogenous antioxidant enzymes. In future, the mechanism of action of the alkaloid fraction of P.amarus must be determined, as well as the isolation of individual alkaloid compounds.