Published Paper Details:

Vitamin D is well acknowledged for calcium homeostasis is a fat soluble vitamin whose scarcity could cause metabolic disorders infectious diseases and rickets and osteomalacia. Mycobacterium tuberculosis (MTB), is an ancient pathogen that through an evolutionally developed complex mechanism to immune surveillance and acquire the ability to establish persistent infection, tuberculosis (TB) in its host. There are emerging evidences suggesting the relation of vitamin D deficiency in establishing tuberculosis. This review summarises the importance of Vitamin D for the treatment of tuberculosis. Since the efficacy has depleted of the Bacille Calmette Guerin (BCG), the only approved TB vaccine so there is a need to investigate for a new vaccine candidate. Previous studies suggest that the incidence and severity of tuberculosis are associated with low levels of Vitamin D and it is associated with an increased risk for emerging active TB infection. In vitro logistical data shows that Vitamin D increase innate immune response against the growth of MTB giving a high dose of Vitamin D on TB patients. Recent studies concluded that the Vitamin D can be recommended for the adjunctive therapy in treating and prevention of TB, in combination with anti-tuberculosis drugs.