Published Paper Details:

Poor aqueous solubility of an active pharmaceutical ingredient are the main constraints during the development of latest product. Various approaches are used for enhancement of solubility of poorly aqueous soluble drugs, but success of those approaches depends on physical and chemical nature of molecules being developed. Cocrystallization of drug substances modified the physicochemical properties such as melting tabletability, solubility, melting point, stability, bioavailability and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient. Cocrystals are multicomponent systems during which the main components are the active pharmaceutical ingredient and a coformer were present in stoichiometric ratio and bonded along side non-covalent interactions in the crystal lattice. This review presents a scientific overview of pharmaceutical cocrystals. The characterization of cocrystals have been summarized and different methods of cocrystal formation and evaluation have been explained.