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ABSTRACT Drynaria quercifolia (L.) J. Smith is an important medicinal plant used in traditional medicinal system by different group of people to treat various kinds of health problems. It is commonly known as oak leaf fern of the family Polypodiaceae of Pteridophyta. It is distributed widely in the evergreen forests of India and is native to tropical areas of Africa, Asia, and Australia and cultivated mostly as a medicinal plant. It plays an important medical role in many countries, especially in Asia. Various phytochemicals like 3,4-dihydroxybenzoic acid, friedelin, epifriedelinol, ?-amyrin, ?-sitosterol and ?-sitosterol 3-?-D-glucopyranoside has been isolated from the plant. The rhizome is reported to have anti-fertility, anti-inflammatory and antipyretic, antimicrobial, antioxidant, wound healing, bone regenerative activity and various other activities of traditional and medicinal uses. This review has been aim to provide scientific information and folklore uses of Drynaria quercifolia as an ethno-medicinal plants.