Published Paper Details:

Dendrimers are wonder molecules of chemistry possess unique characteristics which have improved the physical and chemical characteristics. Due to the presence of terminal groups they show high solubility, reactivity and miscibility. They possess well defined size, shape, molecular weight and monodispersity which make them a suitable carrier in drug delivery and application. The solubility of poorly soluble drugs is enhanced by the unimolecular nature of dendrimers. Dendrimers for drug delivery have been employed using two approaches (1)Forumlation (2)Nano-construct. Drugs are usually entrapped physically in a dendrimer using non-covalent interactions,but in nano-construct drugs are coupled covalently on dendrimers. The use of PAMAM (Poly amido amine) dendrimers have increased the transdermal permeation and solubility, stability and oral bioavailability of various drugs. Dendrimers are engineered to attach targeting ligands and imaging molecules to create a nanodevice. Dendrimers are referred as modern day polymers which offer good properties than conventional polymers. They are employed for drug delivery, genetherapy, chemotherapy. Dendrimer nanotechnology, due to its multifunctional ability has been emerged as the potential to create next generation nano-devices. This review summarizes exclusively classification, synthesis, mechanism of dendrimers and focuses on versatile applications of dendrimers in drug delivery.