Published Paper Details:

Background Coronavirus or COVID-19 is a highly infectious diseases which was first reported in Hubei province of Wuhan city, China and subsequently spread to other countries of world. There were limited studies available in the database on risk of mortality was not well summarized. Current review of observational studies was done to summarize the findings on the association between age, gender, comorbidities and laboratory investigations and risk of death from COVID-19 infection. Methodology PubMed, PubMed Central, EMBASE, MEDLINE were searched for the studies in English language and date specified to after 2020. Results In total, 10 studies were included in this review. A total of 1469 patients included in Non-survivor group, while 22675 patients were included in survivor group. In meta-analysis, significant associations were found between Age (p-value <0.0001), comorbidities like Diabetes (p-value <0.00001), Hypertension (p-value 0.05), Cardiovascular diseases (p-value <0.00001) and risk of death from COVID 19. Additionally, it was also observed that those patients included in non-survivor had elevated levels of D-dimer (MD, -2.73, 95% CI, -5.73 to 0.28), CRP (MD, -66.10, 95% CI, -97.01 to -35.20), Interleukin-6 (MD, -4.70, 95% CI, -7.59 to -1.81), WBC count (MD, -3.88, 95% CI, -5.80 to -1.96) and decreased Albumin levels Albumin (MD, 3.98, 95% CI, 1.66 to 6.29) compared to survivor group. Conclusion Elder age more than 65 years, Hypertension, Diabetes, Cardiovascular diseases, elevated D-dimer, Interleukin-6, WBC count and CRP were mostly associated with mortality in patients with COVID-19. Keywords COVID-19, Mortality, D-dimer, Interleukin-6, CRP.