Published Paper Details:

The purpose of writing this review on sustained release matrix type drug delivery systems as novel drug delivery system is to compile the recent literature with special focus on maintain the desired concentration at the site with specificity. Oral sustained release products provide advantage over conventional dosages forms by optimizing bio-pharmaceutics ,pharmacokinetics properties of drug in such way that it reduced dose frequency to an extent that once daily doses sufficient for penetration, polymer swelling, drug dissolution ,drug diffusion and matrix erosion sustained release matrix tablet is formulated mainly by wet granulation or direct compression or by dispersion of solid particles within a porous matrix formed by using polymer like polymethyl methacrylate (PMMA),polyglycoilic acid ,HPMC can be used in sustained release and thus formed core excipient of the formulation.sustainrd release is also provided promising way to decrease side effect of drug by preventing the fluctuation of the therapeutic concentration of drug in the body. This review article describe the basic information regarding sustained release formulation ,its advantage ,disadvantage, selection of drug for sustained release formulation ,mechanism of release, different type, and factor involved in oral sustained release dosages form design.