Published Paper Details:

Liposome are microscopic spherical vesicles together of one or more outer shell consisting of lipid arranged in bilayers configuration .which are under extensive investigation as drug carrier for improving the delivery of bioactive agent and many different compound in biological ,pharmaceutical, medical and nutritional research .it also utilized in a broad range of pharmaceutical application .liposome were first describe in 1965 and initially as model for studying the biological membrane as drug carrier for several drug to reduce side effect or to deliver the drug at the site of action. Liposome are considered as superior carriers having ability to encapsulated hydrophilic and lipophilic drugs and protect from the degradation. topical liposome formulation might be simpler and fewer toxic than conventional formulation, as a prolonged and controlled drug release. topical dosage form, which may be lead to improved efficiency and better patient compliance. But they have less half-life and poor solubility. The amount of phospholipid and cholesterol, are taken and formulated by using different method like thin film hydration method, sonication method, reverse phase evaporation method, ethanol injection method etc. the liposome formulation characterized by their vesicles size, shape, pH, solubility studies, % of encapsulation efficiency, % of drug content, stability studies, zeta potential, rheology study, in vitro drug release study of liposome formulation.