Published Paper Details:

Introduction: Breast cancer is a malignancy in breast tissue that can originate from the ductal epithelium or lobules. Axillary lymph node status has become one of the strongest prognostic factors in women with early stage breast cancer. Several studies have been conducted to evaluate the relationship of HER-2 with detection, metastasis, and prognosis of breast cancer. This study is aimed at evaluating overexpression of HER2 as a prognostic factor in breast cancer with sentinel lymph node metastases. Methods: This is an analytic study with cross sectional research design. Results: In this study, a sample of 51 people was obtained. Most types of breast cancer are invasive ductal carcinoma in 40 patients (78.4%), then invasive no other specific type in 7 patients (13.7%), then invasive lobular carcinoma and DCIS in 2 patients (3.9%). From the results of statistical tests found no relationship between overexpression of HER-2 with sentinel lymph node metastases (p = 0.255). Patients who had HER2 expression had a 1.477 times greater risk of having sentinel lymph node metastases compared to a group of patients with no HER2 expression. Conclusion: There is no relationship between HER-2 overexpression with the occurrence of sentinel lymph node metastases.