Published Paper Details:

Aim: To investigate the evaluation of various extract of antidiabetic activities of pet.ether, ethyl acetate and ethanolic extract combination of herbal drug. Method: The shade dried herbal drug Trigonella foenum graecum and Withania somnifera powder was extracted with pet.ether, ethyl acetate and ethanol by continuous hot percolation method using Soxhlet apparatus. Results: There was a recognize increment in the body weight in STZ fed group (p<0.001), which was reduced by administration of higher dose of ethyl acetate and ethanolic extract of Trigonella foenum graecum and Withania somnifera (200 mg/kg) than lower dose of ethyl acetate and ethanolic extract of Trigonella foenum graecum and Withania somnifera (100 mg/kg). Evaluate the plasma lipid profile and plasma lipoprotein such as HDL, VDL, VLDL and total cholesterol. The effect of tissue lipid content was free cholesterol, ester cholesterol, phospholipid, triglyceride and free fatty acid. This finding provides some biochemical basis for the use of various extract of dried herbal drug Trigonella foenum graecum and Withania somnifera as hypolipidemic agent having preventive and therapeutic effect against anti-diabetics. Conclusion: Thus, the results of the present study indicate that extracts of highdose, especially the ethanolic extract, showed a significant effect by attenuating the above lipid peroxidation in streptozotocin diabetes.