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Tinospora cordifolia (Giloy) is one of the important as well as very common herb which is normally used as common ingredient in various Falk, Ayurvedic, Unani and Siddha system of medicines. This review article mainly contains theinformationsoncultivation,Harvestingchemical constituents of Tinospora and the therapeutic benefits of this plant like Antiulcer, Antidiabetic, Antiinflammatory, Anticancer, Anti AIDS, Antiallergic activities.Giloy is considered as a most divine herb because of its various Ayurvedic uses. It is called as nectar/Amruta for its divine healing nature. Guluchi increases the immunity of the body. It fights against infecting organisms. The leaves of the plant in juice cure psychological disorder. The leaves are also used for swine flu treatment. It is also used for the treatment of fever due to infection.Guluchi is a remedy for diabetes. The traditional use of the leaves is to cure urine infection and stomach ulcer. Mixed with cow milk, Guluchileaves are used to cure leucorrhoea. It is also used as anti ageing juice. The plant oil is used to cure skin diseases and promote healthy skin. It brings down the high blood sugar. Guluchi purifies blood and levels the blood pressure.Traditionally, Guluchi is used to cure bowel problem. The starch prepared from it called �palo� is popular in India. The leaf juice mixed with cumin seeds is used to cure certain internal inflammation. It is also used to cure rheumatic pain. The leaf extract also used to cure jaundice and anaemia. This also can be used for the treatment of malarial fever and cough. It removes the toxins from the brain. It cures asthma and clears the respiratory tract. The juice of the leaf, root and stem helps in digestion. It also helps to bring down bleeding during menstruation. The juice is also used in the treatment of the cardiac disorder. Guluchi increases memory power. It enhances natural immunity in the human body. Guluchi increases appetite. It purifies milk in mothers. Guluchi adds strength and vigour to the body and removes the weakness. Because of the antioxidant nature, Guluchi is also used in the treatment of cancer. Giloy�s various uses and therapeutic applicability is precisely delineated in this paper.