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This study has been undertaken to assess quality of life of patients suffering with heart disease in selected hospitals in PCMC Pune. Quantitative approach was used with non experimental descriptive survey group design. Non probability purposive sampling technique was used to select the samples. A total of 200 samples were selected to collect the data by using questionnaire. Informed consent was taken from participants after which questionnaire given participants. Data was analyzed by statistical tests such as frequency, percentage, mean standard deviation, chi-square test. Result of the study: A majority of the samples 28.5% were of the age group between 61 yrs to 70 yrs. In the gender 52% of them were females. 26% of them were illiterate. In the occupation majority of samples were workers (16%). In the duration of heart disease 53 % were having heart disease from less than 1year.In physiological dimension 37% of samples were having pain, 60.5% said they are able to do activities of daily living ,51% said they go for marketing and shopping. 56% of samples said they getting sound sleep, 60% are able to eat required meal. 56% of samples don�t have difficulty or straining in passing stool. In psychological dimension 37.5% of samples feel frustrated sometimes and 36% feels frustrated. 40% of samples feel restless, 55% feel irritable, 34.5% didn�t feel loss of selfcontrol,33.5% sometimes and 32% feels loss of selfcontrol.55% were worried about life,36.5% feel hopeless , 57% of samples don�t fear of death , 63% of samples don�t feel burden to family, 74.5% don�t feel taking treatment or medication is worthless. In social dimension 71 % of samples like to meet family members or relatives, 74.5% like to meet friend, 79.5% like to meet colleagues. In financial dimension 52.5% unable to earn money after sickness.Poor social , spiritual and financial quality of life mean % was observed , overall quality of life is average with mean % was 54.91 (28-55) .The satisfactory mean of Physical Domain 1(Mean score 21.45), Psychological domain (mean score 18.28), social domain (mean score 11.71 ) and environmental domain (mean score 24.61) as compare to a raw score, Most SD from mean (SD = 1.94) was observed in DOM 3 (Social Relationships). Greater SD of mean obtained from DOM 2 and DOM 4 might be associated with different interpretations of the questions used in this domain and also small number of questions. Association of demographic variables with quality of life, the p-values corresponding to the gender is small (less than 0.05) was found association of gender with quality of life. For the very purpose monthly time series data has been arranged from Jan 2015 to Dec 2020. Conclusion: Quality of life was found satisfactory in physical, psychological, social and environmental domain. But in social domain there is greater satisfactory result in social relationship. This study suggests that intervention to be implemented to improve all domains of quality of life.