Published Paper Details:

Pulsatile delivery systems getting more attention as they delivered the medication in the desired concentration at the right time, and at the right place results in increases, patient compliances due to it provide spatial, temporal, and smart delivery of a drug. Pulsatile drug delivery is based on the biological rhythm of the body as well as disease rhythm. A pulse should be configured to do so after the lag time, the complete and quick release of drug is achieved. A release of drug from pulsatile drug delivery is mainly achieved by diffusion, erosion, and osmotic mechanism. These systems are useful for those drugs which show chronopharmacological nature such as the drugs used in the treatment of cardiovascular diseases, bronchial asthma, osteoarthritis, diabetic mellitus, ankylosing spondylitis, and peptic ulcer. The first part of this article deals with the chronobiology of the body and diseases, benefits and limitations, reason behind the development of this system. The last part of the article deals with marketed technologies, methods of development of pulsatile delivery systems, and its characterization.