Published Paper Details:

Drug delivery systems including chemical, physical and biological agents which will enhance the bioavailability, improve pharmacokinetics and reduce toxicities of the drugs. Carrier erythrocytes are one among the foremost promising biological drug delivery systems investigated in recent decades. Resealed erythrocytes are biodegradable biocompatible, possess long circulation half-life and can be loaded with sort of active drug substances. Resealed erythrocyte possesses several advantages over the other drug delivery system which makes it superior than other systems. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and isolate erythrocytes from plasma. By using various methods, the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and therefore the resultant carriers are then called "resealed erythrocytes". Resealed erythrocytes, as a drug delivery system has excellent capacity to reinforce the therapeutic index and patient compliance. It has got tremendous potential to achieve site specific drug delivery with minimum wastage of drugs and it also prolong the discharge of drug. So many drugs like aspirin, steroid, antineoplastic which having many side effects are reduce by resealed erythrocyte. The present review signifies various features, drug loading methods, evaluation, applications and clinical progress of resealed erythrocytes