Published Paper Details:

The colon targeted drug delivery system is to provide a high concentration of therapeutic agent at the site of action while minimising pre-mature drug release in the upper gastrointestinal tract such as stomach, small intestine, large intestine and thus reducing the emergence of adverse effects to nontargeted areas. In prepared standard marketed formulations such are microsphere, capsule, delayed-release tablet and pellets are mainly used. These formulations are used for reducing the inflammation of colon. The aim of present study was based upon solid dispersion technique and to reducing the frequency of dose administration, to prevent ulcerative colitis by developing compressed coated tablet and this tablet is coating with solid dispersion by using Polyethylene glycol (PEG-4000). We were performed evaluation characteristics of core tablets and compressed coated tablets. The in-vitro drug dissolution study was conducted by using phosphate buffer pH7.4. The result demonstrated that the compressed coated tablet showed a drug release of 98.7% for 12 h. We will investigate the further study for the exact mechanism related to finding of the study.