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In the present study, Mucoadhesive floating drug delivery systems of sitagliptin Phosphate, is an anti diabetic Agent , have been designed to increase the buyoncy, gastric residence time and to reduce frequency of administration. In an attempt to developed ?oating beads of Sitagliptine, drug loaded alginate beads were prepared by simultaneous external and internal gelation. The effect of blending of Sodium alginate with Calcium carbonate and chitosan on the bead properties were evaluated. Beads were spherical with Entrapment ef?ciency in the range of 52.81�2.64 to 78.95�1.92%. Beads exhibited buoyancy over a period of 7�24 hr based on the formulation variables. In vitro release of Sitagliptine from the alginate beads in simulated gastric ?uid (SGF) (0.1 N HCl, pH 1.2), was in?uenced signi?cantly (p < 0.001) by the properties and concentration of additives. Among the polymers incorporated into alginate beads. The Sodium Alginate provided an extended release over 12 hr.