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Introduction: Prosthetic valve endocarditis (PVE) and cardiac device-related infective endocarditis (CDRIE) are the most severe forms of infective endocarditis (IE), they are burdened with a heavy morbidity-mortality. Method: We present a retrospective study of a series of 35 cases of PVE and CDRIE collected in the cardiology department B at CHU IBN SINA, between January 2015 and December 2019. Objectives: Analyse, on the one hand, the epidemiological, clinical, bacteriological and anatomical characteristics of the PVE and CDRIE, and, on the other hand, the risk factors, and the therapeutic and prophylactic modalities of these forms of endocarditis. Results: The epidemiological profile of our patients was dominated by male sex with an average age of 52.8 years. Of the 35 patients, 10 had early infective endocarditis (IE) and 25 had late IE. Clinical signs were dominated by fever in 71% of patients and local signs in 76% of patients with CDRIE. All of our patients received blood cultures on the first day of admission. HC was negative in 10 patients (28%), for the other 25 (72%) we noted a slight predominance of staphylococci followed by streptococci and BGN. Echocardiography especially transesophageal was of a fundamental contribution to the diagnosis by allowing objectifying for the PVE: vegetations (10 cases, 45%), paravalvular abscesses (3 cases, 13%), dehiscence of the prosthetic valve (3 cases, 13%), and prosthetic leaks (8 cases, 36%). For CDRIE: Probe thickening in 9 patients (69%) and vegetations in 10 cases (76%). Treatment in 81% of patients with antibiotics was medical with a duration of antibiotic therapy of at least 6 weeks and medico-surgical in 18% of patients. Concerning the CDRIE treatment was based on all patients on the extraction of the infected equipment plus antibiotic therapy.4 patients had died; they were all patients with PVE. No deaths or complications were reported in patients with CDRIE. Conclusion: Through this work we insist on the need to shorten the time of diagnosis by educating patients to avoid the empirical consumption of antibiotics, the systematic realization of echocardiography especially transoesophageal and blood cultures. Due to the reserved prognosis, surgery, when indicated, should not be delayed and antibiotic prophylaxis should never be neglected.