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Ayurveda advocates a range of promotive, preventive and curative measures. Amavata word is composed of two words Ama and Vata, the condition which is caused by accumulation of Ama and Vata and it is Madhyam roga Marga vyadhi. In Vedic kale, only Atharva Veda mentioned the Sandhi related vyadhi. In various samhita, the fragmented description of Amavata is available. But only in Madhava Nidana, separate chapter is mentioned about the etiology, clinical features, types and prognosis of Amavata. Amavata is vyadhi developed due to hetu like Vriddha Ahar result in formation of Ama (unripe Ahar rasa).Agnimandya, Aruchi, Daurbalya, Apaka are the Purvarupa are seen before the actual expression of vyadhi. The types of Amavata are described on the basis of chronicity, prognosis, and Doshanubandha. The sign and symptoms of Amavata are divided under the heading of Pratyatma Lakshana, Samanya Lakshana, Doshanubandha Lakshana, and Pravridha Amavata Lakshana. Ama is produced due to the hetu sevana and vataprakopa leads to the khavaigunya at sandhi (Shleshma sthana). Circulating Ama with excessively vitiated vata simultaneously gets accumulated in sandhis.Vata acts as avaraka and blocks srotasas.Hence Shotha and pain occurs in sandhi. Thus finally it produces Amavata. Madhavnidankar mentioned various updrava of Amavata. Ek doshaj Amavata is sadhya while sannipatika Amavata is Krucchasadhya.Ushna Ahar vihar is Pathyakara in Amavata vyadhi. Amavata has similarities to many arthritic diseases with specific clinical features associated with Rheumatoid Arthritis.