Published Paper Details:

Aquasomes are one of the most recently developed delivery mechanism to different sites for bioactive molecules such as peptides, proteins, hormones, antigens, and genes. Aquasomes are circular, with particle size of 60300 nm. Aquasomes are spherical particles formed from calcium phosphate or ceramic diamond coated with a polyhydroxy oligomeric film and acting as a network of nanoparticulate carriers, but rather than a pure nanoparticle. There are three layers of self-assembled structures consisting of a solid phase nanocrystalline core coated with oligomeric film adsorbing biochemically active molecules with or without modification... It is commonly used in implant preparation. Aquasomes used as RBC replacements, vaccines for viral antigen delivery and as a targeted method for intracellular gene therapy. The behavior and responsiveness of enzymes to molecular conformation made aquasomes a novel carrier of enzymes such as DNAs and pigments. This article discusses the concepts of self-assembly, the difficulties of preserving pairs of immobilized surfaces with both conformational integrity and biochemical operation. Successfully the delivery system was used to distribute insulin, hemoglobin, and enzymes such as serrati peptidase etc.