Published Paper Details:

ABSTRACT: Objective: Mouth dissolving films these are novel dosage forms it comes under fast dissolving drug delivery system. It disintegrates or dissolves within the oral cavity. It does not require water for administration so that it is convenient for medications for the pediatric and geriatric patients which have the difficulty in swallowing. This research work was aimed to enhance the oral bioavailability and provide faster onset of action of Tadalafil by formulating its mouth dissolving film (MDF). Method: The MDF of Tadalafil was prepared by solvent casting method. Tadalafil it is a BCS class II and it has the oral bioavailability of about 28%. HPMC k-15, Xanthan gum, Sodium alginate (film forming agent), Glycerol (plasticizer), Tween 80 (solubilizing agent), Citric acid (saliva stimulating agent), Sucrose (sweetening agent), vanillin (flavoring agent), Propyl paraben (preservative). The formulation was evaluated for weight variation, thickness, folding endurance, drug content, disintegration time and in-vitro dissolution study stability study. Conclusion: Based on the results F2 was showed enhanced bioavailability and rapid onset of action as compared to other dosage form.