Published Paper Details:

Acute Otitis Media (AOM) is a common ear disease encountered in children below three years. Amoxicillin clavulanate is the first line drug in treatment of AOM in paediatric age group. Although Cefpodoxime has shown good antimicrobial activity against various types of pathogen that are labelled as main causative microorganisms of AOM in paediatric age group. In this study to try to compare the efficacy and safety of cefpodoxime and amoxicillin clavulanate in the treatment of AOM in children below three years of age. This study was a prospective longitudinal study which was conducted on children diagnosed with AOM who were less den three years of age. 30 children were included in our study, 15 in the Group A (amoxicillin clavulanate) and 15 in the Group B (cefpodoxime). The outcome of the study was assessed in two variants one was the clinical success rate at day 7 visit and other was any incidence of some kind of Adverse Events during the treatment period. The clinical success rates were 94.4% in Group A and 93.4 % in Group B. These rates were comparable with no statistically significant difference between the two groups. No side effects and adverse effects were observed in cefpodoxime group and the drugs were well tolerated in all patients whereas diarrhea was seen in three patients who were put on amoxicillin. The results of our study showed that a 7 day course of cefpodoxime was found to be therapeutically comparable to amoxicillin-clavulanate in terms clinical success with diarrhoea being seen in two patients who were put on amoxicillin clavulanate for the treatment of AOM in children below three years of age.