Published Paper Details:

Vaccines comes under the branch of biotechnology which are one of the most important tools used worldwide for prevention of life threatening infectious diseases. Although, the major problem for the oral immunization is the digestion of macromolecule antigenic protein inside the stomach because of extremely acidic pH. To solve this problem, scientist Arntzen developed the theory of edible vaccines (EVs). Edible vaccines are prepared by exposing the selected desired genes into the plants and then using these altered plants for the production of encoded proteins. The altered plants are known as ��transgenic plants�� and the process is called as ��transformation�� in terms of biotechnology. Edible vaccines are generally GM crops which provide immunity against the diseases such as HIV, cancer, Hep. B, pneumonia. The main strategies based upon edible vaccines formulations has been demonstrated to increase both systemic as well as mucosal immune response. This novel vaccination delivery systems having various advantages over injectable vaccination preparations including stability, self-administration, reduced cost, and elimination of cold chain. In this review the latest findings related to edible vaccines are discussed including the mechanism of action, preparation methods, applications, advantages, disadvantages, limitations, and future of edible vaccines is also discussed.