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ABSTRACT Narrating a story in an effective way is always been a challenge. In case of narrating �illness� it cannot be trouble-free. Various human conditions provide various meanings of illness. Illness offers ample number of perceptions and connotations. Arthur Kleinman, a prominent American Psychiatrist, in his theoretical work, The Illness Narratives, views illness in a wider perspective. He states, �by invoking the term illness, I mean to conjure up the innate human experience of symptoms and sufferings. Illness refers to how the sick person and the members of the family or wider social network perceive, live with, and respond to symptoms and disability.� Thus illness becomes part and parcel of human life and suffering. It moulds the thoughts of the society; manipulates and gears human life, invades people�s thoughts and inhabits their memories. It occurs often in conversations of the sick and in the people surrounded them. A person�s health and mental conditions change according to the despotism of illness and mould lives, thoughts and creative processes. In a nutshell illness more often mirror the society. Illness in its wider sense represents suffering, misery, pain, death, the question of existence and so on. On the other hand it also lays a hand on inter/intra personal human relationships, empathy, ethics and care. When illness holds its influence on human life, unsurprisingly it reflects in literature, which in turn reflects human embeddedness with illness. A patient is not only an object of medical query, but also a �narrator of suffering�. Some narrators can effectively represent the sufferings of the ill, but it is not effortless. This paper tries to understand how illness is represented in Jodi Picoult�s novel My Sister�s Keeper. It is also intended to go deep into the techniques used to narrate illness.